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Ketamine Academy Blog Post

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Improving Patient Outcomes: Intravenous Ketamine for Late-Life Treatment-Resistant Depression

Hey there, Healthcare Bosses! Let's dive into the world of mental health and explore an exciting new treatment for late-life Treatment-Resistant Depression (TRD).

Depression: A Silent Killer in the Elderly

Depression in the elderly is a serious issue. It increases the risk of physical disability, dementia, and overall mortality. But here's the good news: all these can be mitigated with treatment. And when we talk about treatment, we're not just referring to the remission of depression. We're also looking at psychological well-being, sleep, and suicidality - all crucial patient-centered outcomes linked to overall well-being.

IV Ketamine: The New Kid on the Block

Enter Intravenous (IV) Ketamine. This isn't your average party drug, folks. In a recent open-label trial, participants aged 60 years or older with late-life TRD were treated with twice-a-week IV ketamine for four weeks. Those who showed significant improvement proceeded to the continuation phase, which involved an additional four weeks of once-a-week IV ketamine.

The Results are In

The results? Psychological well-being, sleep, and suicidality improved during the acute phase and these improvements were sustained during the continuation phase. In fact, those who had greater improvements in their depression scores saw even greater improvements in psychological well-being and sleep. And here's the kicker: all but one of the participants with high suicidality at baseline improved, with no cases of treatment-emergent suicidality.

Hot Take

This is a game-changer, Healthcare Bosses. IV Ketamine could potentially revolutionize the treatment of late-life TRD. But let's not get ahead of ourselves. While these findings are promising, a larger and longer controlled trial is needed to confirm and extend these findings.

So, let's keep our fingers crossed and our eyes on the prize. Because if these findings hold up, we could be looking at a brighter, happier future for our elderly population. And that's a future worth fighting for.

Remember, Healthcare Bosses, mental health matters at every age. Let's continue to innovate, educate, and advocate for better mental health treatments and outcomes.

This post was written based on content from this original Article


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